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Uracil DNA glycosylase interacts with the p32 subunit of the replication protein A complex to modulate HIV-1 reverse transcription for optimal virus dissemination

2016; BioMed Central; Volume: 13; Issue: 1 Linguagem: Inglês

10.1186/s12977-016-0257-x

1742-4690

Cécile Hérate, Clarisse Vigne, Carolin A. Guenzel, Marie Lambelé, Marie-Christine Rouyez, Serge Bénichou,

DNA Repair Mechanisms

Through incorporation into virus particles, the HIV-1 Vpr protein participates in the early steps of the virus life cycle by influencing the reverse transcription process. We previously showed that this positive impact on reverse transcription was related to Vpr binding to the uracil DNA glycosylase 2 enzyme (UNG2), leading to enhancement of virus infectivity in established CD4-positive cell lines via a nonenzymatic mechanism.