Isolation of 1-(p-Hydroxybenzyl)-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (demethylcoclaurine), an Active Alkaloid from Nelumbo nucifera

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Isolation of 1-(p-Hydroxybenzyl)-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (demethylcoclaurine), an Active Alkaloid from Nelumbo nucifera

1970; Pharmaceutical Society of Japan; Volume: 18; Issue: 12 Linguagem: Inglês

10.1248/cpb.18.2564

ISSN

1347-5223

Autores

Hideo Koshiyama, HIROAKI OHKUMA, Hiroshi Kawaguchi, Hong-Yen Hsū, YUHPAN CHEN,

Tópico(s)

Synthesis and Biological Activity

Resumo

One of the alkaloidal components of Nelumbo nucifera embryo was isolated in crystalline form and identified with 1-(p-hydroxybenzyl)-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline. This is the first tetrahydroisoquinoline alkaloid with a secondary base isolated from Nelumbo nucifera.

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Isolation of 1-(p-Hydroxybenzyl)-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (demethylcoclaurine), an Active Alkaloid from Nelumbo nucifera