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Recombinant Mouse Interferon-γ Is Not Chemotactic for Macrophages or Neutrophils

1989; Mary Ann Liebert, Inc.; Volume: 9; Issue: 1 Linguagem: Inglês

10.1089/jir.1989.9.79

2332-4007

B P Canono, Marjorie H. Middleton, P A Campbell,

Escherichia coli research studies

Recent evidence implicates interferon-γ (IFN-γ) in resistance to infection with the facultative intracellular bacterium, Listeria monocytogenes. Reports showing that inflammatory macrophages and neutrophils are highly bactericidal for listeria suggest that IFN-γ might act by directly or indirectly causing recruitment of these cells. The purpose of the experiments described here was to test whether recombinant mouse IFN-γ is chemotactic for macrophages or neutrophils in vivo or in vitro. In vivo experiments showed rIFN-γ to have no ability to cause recruitment of inflammatory neutrophils or macrophages into the peritoneal cavities of mice. When tested in vitro, rIFN-γ also did not induce migration of inflammatory neutrophils or macrophages through cellulose nitrate filters in a chemotaxis assay. The data indicate that rIFN-γ has no direct or indirect chemotactic activity in vivo or in vitro for mouse macrophages or neutrophils.