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Mandibular Ewing Sarcoma With Chromosomal Translocation t(21;22)(q22;q12)

2013; Lippincott Williams & Wilkins; Volume: 24; Issue: 4 Linguagem: Inglês

10.1097/scs.0b013e31829030ed

1536-3732

Maiko Shibasaki, Toshinori Iwai, Jiro Maegawa, Yoshiaki Inayama, Tomoko Yokosuka, Shumpei Yokota, Shinsuke Ohta, Yoshiro Matsui, Kenji Mitsudo, Iwai Tohnai,

Lymphoma Diagnosis and Treatment

Ewing sarcoma (ES) is a primary bone malignant neoplasm and is the second most common primary malignancy of the bone found in childhood and adolescence after osteosarcoma. ES has an annual frequency in the population younger than 20 years of approximately 2.9 per million. ES occurs most frequently in the long bones of the extremities and pelvis and very rarely in the jaw. Recently, it was revealed that chromosomal translocation t(11;22)(q24;q12), which fuses the EWS gene on chromosome 22 and the FLI-1 gene on chromosome 11, occurs in most cases of ES. We report here a rare case of mandibular ES in a 10-year-old child with chromosomal translocation t(21;22)(q22;q12) in which the EWS gene is fused with the ERG gene on chromosome 21.