Identification of Basement Membrane Components in Eosinophilic Globules in a Case of Spitzʼs Nevus
1990; Lippincott Williams & Wilkins; Volume: 12; Issue: 3 Linguagem: Inglês
10.1097/00000372-199006000-00008
ISSN1533-0311
AutoresC Schmoeckel, W Stolz, Robert E. Burgeson, Thomas Krieg,
Tópico(s)Contact Dermatitis and Allergies
ResumoA case of Spitz's nevus with eosinophilic globules was examined using antibodies for several components of the basement membrane. Aggregated tumor cells revealed the same characteristics as normal nevocytic nevi, that is, they were surrounded by laminin and type-IV collagen, whereas type-VII collagen was absent. All of these components of basement membranes, including type-VII collagen, were also found in eosinophilic globules, which were densely stained by these antibodies. It is assumed that these eosinophilic globules are essentially composed of basement membrane components, which are probably synthesized by epidermal and possibly also by melanocytic tumor cells.
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