Paracaseolide A, First α-Alkylbutenolide Dimer with an Unusual Tetraquinane Oxa-Cage Bislactone Skeleton from Chinese Mangrove Sonneratia paracaseolaris
2011; American Chemical Society; Volume: 13; Issue: 19 Linguagem: Inglês
10.1021/ol201809q
ISSN1523-7060
AutoresXuelian Chen, Haili Liu, Jia Li, Guorong Xin, Yue‐Wei Guo,
Tópico(s)Natural product bioactivities and synthesis
ResumoA novel α-alkylbutenolide dimer, paracaseolide A (2), characterized by an unusual tetraquinane oxa-cage bislactone skeleton bearing two linear alkyl chains, was isolated from the mangrove plant Sonneratia paracaseolaris. The structure of 2 was elucidated by extensive spectroscopic analysis. A plausible retrosynthetic pathway for paracaseolide A (2) was proposed. Compound 2 exhibited significant inhibitory activity against dual specificity phosphatase CDC25B, a key enzyme for cell cycle progression, with an IC50 value of 6.44 μM.
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