A critical appraisal of mitogen-induced lymphocyte proliferation in depressed patients
1991; American Psychiatric Association; Volume: 148; Issue: 3 Linguagem: Inglês
10.1176/ajp.148.3.337
ISSN1535-7228
AutoresDenis F. Darko, Nathan Wilson, J. Christian Gillin, S. Golshan,
Tópico(s)Mental Health Research Topics
ResumoBack to table of contents Previous article Next article No AccessA critical appraisal of mitogen-induced lymphocyte proliferation in depressed patientsPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.148.3.337AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: The authors' goal was to evaluate the utility of mitogen- induced lymphocyte proliferation assays in clinical research in psychoimmunology. METHOD: They examined 23 depressed patients and 23 matched comparison subjects with this assay. There were no significant differences between these groups. They then combined the results of this study with the results of their previous study of 20 depressed patients and 20 comparison subjects to examine possible determinants of lymphocyte proliferation in depression. RESULTS: Depressed patients with lower proliferative responses than their matched comparison subjects had lower depression subscale, anergia subscale, and total scores on the Brief Psychiatric Rating Scale than did patients with higher proliferative responses than their matched comparison subjects. This finding was unexpected and unexplained. Depressed patients with lower proliferative responses than their matched comparison subjects also had fewer obsessions and compulsions and less psychomotor agitation according to the Schedule for Affective Disorders and Schizophrenia interview than did patients with higher proliferative responses than their matched comparison subjects. Stepwise discriminant analysis and cluster analysis contributed little further understanding of the determinants of in vitro lymphocyte proliferation of cells from depressed patients. CONCLUSIONS: Longitudinal studies using multiple serial determinations of mitogen-induced lymphocyte proliferation are the minimal design needed to make this assay useful in further evaluating any immune system changes in depression. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byImmune function and adjustment style: Do they predict survival in breast cancer?3 June 2003 | Psycho-Oncology, Vol. 13, No. 3Brain, Behavior, and Immunity, Vol. 15, No. 3Cytokine Production in Depressed Patients23 November 2007Biological Psychiatry, Vol. 45, No. 8Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 22, No. 1, Vol. 80Psychosomatic Medicine, Vol. 57, No. 6Scandinavian Journal of Immunology, Vol. 41, No. 6Acta Psychiatrica Scandinavica, Vol. 92, No. 4Stress Medicine, Vol. 10, No. 1Biological Psychiatry, Vol. 35, No. 1Journal of Psychosomatic Research, Vol. 38, No. 6Psychiatry Research, Vol. 52, No. 1, Vol. 25The effects of chronic lithium chloride administration on some behavioural and immunological changes in the bilaterally olfactory bulbectomized rat1 July 2016 | Journal of Psychopharmacology, Vol. 8, No. 1Annals of Medicine, Vol. 25, No. 5Association of beta-endorphin with specific clinical symptoms of depression1 April 2006 | American Journal of Psychiatry, Vol. 149, No. 9Psychiatry Research, Vol. 43, No. 2 Volume 148Issue 3 March 1991Pages 337-344 Metrics PDF download History Published online 1 April 2006 Published in print 1 March 1991
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