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Spurious Erythrocyte Indices as Measured by the Model S Coulter Counter due to Cold Agglutinins

1971; Oxford University Press; Volume: 56; Issue: 4 Linguagem: Inglês

10.1093/ajcp/56.4.500

1943-7722

John V. Petrucci, Patricia A. Dunne, C. Constance Chapman,

Erythrocyte Function and Pathophysiology

Brittin and associates reported that the spurious macrocytosis caused by antibody-coated erythrocytes did not occur when this parameter was measured by the Coulter counter model S. We have encountered at least two definite cases in which spurious macrocytosis as well as spurious mean corpuscular hemoglobin concentration and mean corpuscular hemoglobin values were obtained using this instrument. These were due to cold agglutinins. The clue to each of these cases was a mean corpuscular hemoglobin concentration of more than 36%. The combination of this finding with elevated mean corpuscular volume and mean corpuscular hemoglobin values should prompt a search for cold agglutinins.