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Enantio- and Regioselective Iridium-Catalyzed Allylic Hydroxylation

2011; American Chemical Society; Volume: 133; Issue: 7 Linguagem: Inglês

10.1021/ja109953v

1943-2984

Martin Gärtner, Steffen Mader, Kai Seehafer, Günter Helmchen,

Synthetic Organic Chemistry Methods

The first enantioselective allylic hydroxylation to prepare branched allylic alcohols directly is described. Bicarbonate was used as nucleophile in conjunction with new single component Ir-catalysts, which are stable to air and water. Excellent regio- and enantioselectivities have been achieved with a representative set of substrates.