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CRH1- and GR-gene SNPs and haplotypes: Associations with response to Dex/CRH test and antidepressant treatment?

2004; Thieme Medical Publishers (Germany); Volume: 36; Issue: 05 Linguagem: Inglês

10.1055/s-2003-825578

1439-0795

Astrid Zobel, Barbara Hoefgen, Sibylle G. Schwab, Olrik von Widdern, Martin Metten, Wolfgang Maier,

Adipose Tissue and Metabolism

Hormones of the HPA system and their receptors, especially CRH1 receptors and GR, which are highly polymorphic in humans, are involved in the pathophysiology and treatment of depression. Multiple functional variants might contribute to the broad interindividual variation of the set point of the HPA system activity in depression and response to treatment.