Portal de Periódicos da CAPES

Studies on Tablets. III. Weight Variation of Compressed Tablets.

1957; Pharmaceutical Society of Japan; Volume: 5; Issue: 1 Linguagem: Inglês

10.1248/cpb1953.5.15

1881-1345

Jun Hasegawa,

Drug Solubulity and Delivery Systems

Tablets were compressed during a short period, its weight variation was evaluated as coefficient of variance in percentage, and the effect of four factorials was examined. From the results obtained, following conclusions were drawn : 1) Significant difference was not recongnized among tablet bases A, B, and C. 2) Decrease of diameter of punch increased the weight variation of tablets quadratically. 3) Increase of the granulated sieve mesh decreased weight variation of tablets, and linear relation was proved between them. 4) The degree of decrease was different for each punch. 5) Significant difference was not recognized between two compression rates, 76 and 42 tabs./min. 6) Without considering variation of mean weight for a long-period operation of a tabletting machine, from the OC-curve obtained by Dunnett and Crisafio, and 95% and 99% confidence limits of regression line for each punch, compression of tablets under the conditions listed in Table IV is recommended. The lot manufactured under such conditions may be accepted by U.S.P. test in probability of 0.95×0.95=0.90 and 0.99×0.95=0.94.