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Cortical Thinning in Verbal, Visual, and Both Memory-predominant Mild Cognitive Impairment

2011; Lippincott Williams & Wilkins; Volume: 25; Issue: 3 Linguagem: Inglês

10.1097/wad.0b013e3182076d31

1546-4156

Min Jeong Kim, Kiho Im, Jong Min Lee, Aram Park, Juhee Chin, Geon Ha Kim, Jong Hun Kim, Jee Hoon Roh, Sang Won Seo, Duk L. Na,

Glaucoma and retinal disorders

The amnestic form of mild cognitive impairment (aMCI) is likely a precursor of Alzheimer disease (AD). Both verbal and visual memory tests are used in the diagnosis of aMCI; however, it is unknown which type of test is superior at predicting the underlying pathologic changes associated with AD. In this study, we compared the topography of cortical thinning among 3 subtypes of patients with aMCI: 33 patients with predominant verbal memory impairment (verbal-aMCI), 35 with predominant visual memory impairment (visual-aMCI), and 56 with both verbal and visual memory-predominant impairment (both-aMCI), and 143 patients with normal cognition. As a result, patients with verbal-aMCI showed cortical thinning in the left anterior and medial temporal regions compared with individuals with normal cognition, while those with visual-aMCI did not show significant cortical thinning. The cortical thinning areas of both-aMCI group overlapped those of verbal-aMCI but were more widespread involving the bilateral temporal regions. These findings suggest that the verbal-aMCI and both-aMCI are more likely to be a precursor of AD than visual-aMCI, and that both-aMCI may be more advanced subtype than verbal-aMCI on the spectrum from MCI to AD.