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CD30 Positive Atypical Lymphocytes in Perniosis

2014; Lippincott Williams & Wilkins; Volume: 36; Issue: 9 Linguagem: Inglês

10.1097/dad.0000000000000109

1533-0311

Paul R. Massey, Kari A. Wanat, Campbell L. Stewart, Ellen J. Kim, Leslie Castelo‐Soccio, Rosalie Elenitsas, Adam I. Rubin,

Lymphadenopathy Diagnosis and Analysis

In classical clinical perniosis (chilblains), the presence of atypical lymphocytes with immunohistochemical staining positive for CD30 is unusual and rarely reported. Here we report 2 cases of clinical perniosis, one in a 16-year-old girl and another in a 67-year-old woman. The biopsies revealed lymphocytic infiltrates, papillary dermal edema, and atypical cells highlighted with a CD30 immunohistochemical stain. Our cases demonstrate the importance of clinicopathologic correlation in the assessment of CD30 positive lymphocytes in benign nonneoplastic conditions. Dermatopathologists must be aware of this potential histologic pattern in perniosis to prevent misdiagnosis and overtreatment of this condition.