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Pill Burden Influences the Association Between Time-Based Prospective Memory and Antiretroviral Therapy Adherence in Younger But Not Older HIV-Infected Adults

2016; Lippincott Williams & Wilkins; Volume: 27; Issue: 5 Linguagem: Inglês

10.1016/j.jana.2016.03.006

1552-6917

David P. Sheppard, Erica Weber, Kaitlin B. Casaletto, Gunes Avci, Steven Paul Woods, Igor Grant, Hampton J. Atkinson, Ronald J. Ellis, Allen McCutchan, Thomas D. Marcotte, Jennifer Marquie‐Beck, Melanie A. Sherman, Scott Letendre, Edmund V. Capparelli, Rachel Schrier, Debra Rosario, Robert K. Heaton, Mariana Cherner, Jennifer E. Iudicello, David J. Moore, Erin E. Morgan, Matthew Dawson, Terry L. Jernigan, Christine Fennema‐Notestine, Sarah Archibald, John R. Hesselink, Jacopo Annese, Michael J. Taylor, Eliezer Masliah, Cristian L. Achim, Ian Everall, Douglas D. Richman, David M. Smith, Stuart A. Lipton, Anthony Gamst, Clint Cushman, Ian Abramson, Florin Vaida, Reena Deutsch, Anya Umlauf,

HIV/AIDS Research and Interventions

Prospective memory (PM) is associated with antiretroviral (ARV) adherence in HIV, but little is known about how pill burden and age might affect this association. One hundred seventeen older (≥50 years) and 82 younger (<50 years) HIV-infected adults were administered a measure of PM in the laboratory and subsequently were monitored for ARV adherence for 30 days using the Medication Event Monitoring System. In the older group, better time-based PM performance was associated with higher likelihood of adherence, irrespective of pill burden. Within the younger sample, time-based PM was positively related to adherence only in participants with lower pill burdens. Younger HIV-infected individuals with higher pill burdens may overcome the normal effects of time-based PM on adherence through compensatory medication-taking strategies, whereas suboptimal use of these strategies by younger HIV-infected individuals with lower pill burdens may heighten their risk of ARV nonadherence secondary to deficits in time-based PM.