Portal de Periódicos da CAPES

Oral administration of liposomally-entrapped heparin to beagle dogs.

1982; Pharmaceutical Society of Japan; Volume: 30; Issue: 6 Linguagem: Inglês

10.1248/cpb.30.2245

1347-5223

Masaharu Ueno, Takashi Nakasaki, Isamu Horikoshi, N Sakuragawa,

Proteoglycans and glycosaminoglycans research

The oral administration of heparin alone or entrapped in liposomes was investigated. The prolongation of clotting time (a-PTT) was observed after administration of heparin and attributed to an increase of heparin activity in the blood as a result of effective absorption from the intestine. The increase of heparin activity was promoted by entrapping heparin in liposomes, but not by mere addition of empty liposomes.