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Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI 2 and FeCl 3

2012; American Chemical Society; Volume: 14; Issue: 17 Linguagem: Inglês

10.1021/ol301980g

1523-7060

Gopal Chandru Senadi, Wan‐Ping Hu, Jia‐Shing Hsiao, Jaya Kishore Vandavasi, Chung‐Yu Chen, Jeh‐Jeng Wang,

Synthesis and Catalytic Reactions

An expedient method for a direct approach to the selective and regiocontrolled synthesis of 2-oxazolines and 2-oxazoles mediated by ZnI2 and FeCl3 is described. A Lewis acid promoted cyclization of acetylenic amide with various functionalities was well tolerated to give 2-oxazolines and 2-oxazoles in good to excellent yields under mild reaction conditions.