Portal de Periódicos da CAPES

Development of Intramolecular Vicinal Diamination of Alkenes: From Palladium to Bromine Catalysis

2013; American Chemical Society; Volume: 78; Issue: 6 Linguagem: Inglês

10.1021/jo302472w

1520-6904

Kilian Muñiz, Claudio Martínez,

Alkaloids: synthesis and pharmacology

Palladium catalysis has been instrumental in the development of the intramolecular diamination of alkenes. Reagent combinations of a palladium catalyst and iodosobenzene diacetate or copper(II) salts, respectively, represent the broad applicability and mechanistic variation. Recent work has established alternative copper and bromine catalysts. The occupation with this reaction has also contributed to the development of high oxidation state metal catalysis in alkene difunctionalization and significantly broadened the spectrum of Pd-catalyzed C–N bond-forming reactions in general.