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Effect of acute administration of selective serotonin reuptake inhibitors (SSRIs) in different ultrasonic vocalization test paradigms

2009; Frontiers Media; Volume: 3; Linguagem: Inglês

10.3389/conf.neuro.01.2009.04.092

1662-5137

István Gyertyán,

Infant Health and Development

Event Abstract Back to Event Effect of acute administration of selective serotonin reuptake inhibitors (SSRIs) in different ultrasonic vocalization test paradigms Ferenc Kassai1* and Istvan Gyertyan1 1 Gedeon Richter Plc., Hungary SSRIs are widely applied in the human medicine in order to ameliorate anxiety symptoms. However, at the first phase of the treatment SSRIs are anxiogenic, their anxiolytic effect develops only later. Contrarily, SSRIs show anxiolytic like effect in different animal models even after acute administration. In our experiments, we studied the efficacy of acutely administered SSRIs (sertraline, fluoxetine, paroxetine, escitalopram) in different experimentally elicited anxiety states in the ultrasonic vocalization (USV) paradigm in the rat. The experiments were carried out on Hannover Wistar (Wobe) rats (200-250 g on arrival). USV was elicted by six 0.6 mA shocks in a 30X30X20 cm shocking chamber during a daily shocking session. Total time of ultrasonic vocalisation was measured right after the last shock (or right after replacement to the context in case of the context conditioning paradigm) for ten minutes with a Noldus Ultravox system. Inhibition of USV was determined as percentage change compared to the control. Three test setups were used. In the acute stress paradigm animals were shocked only in a single shocking session. SSRIs (fluoxetine, sertraline, escitalopram and paroxetine) were administered i.p. 30 minutes before shocking. In the context condtitioned model animals were shocked on two consecutive days. On the third day rats were replaced into the box, but shock was not administered. In this case USV was elicited by the context. Test compounds were given 30 min before the third session. In the multiple shocking setup (the most often applied one to test anxiolytics) animals were shocked weekly on two consecutive days. Drug administrations took place on the second occasion except the first week when no drug treatment was carried out. USV of the same groups of animals on the day before the drug administration was considered as control value. Fluoxetine, sertraline and paroxetine was ineffective in the acute stress model, while escitalopram reduced vocalizations only at a very high dose. In the context conditioned setup all compounds reduced vocalizations with ED50 values between 0.57 mg/kg and 9.1 mg/kg. In the multiple shocking setup all compounds were effective. The dose-response curve of fluoxetine and sertraline was bell shaped with 58 and 62% maximal effect respectively. The dose-response curves of paroxetine and escitalopram were linear, however, maximal effect was below 50% in case of both drugs. SSRIs after acute administration showed anxiolytic effect in those experimental setups, where animals have previous experience with the stressor. A possbile explanation may be that stress elicits adaptive changes in the nervous system and these adaptive changes may enable SSRIs to have anxiolytic effect even after acute administration. Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Behavioural neuroscience Citation: Kassai F and Gyertyan I (2009). Effect of acute administration of selective serotonin reuptake inhibitors (SSRIs) in different ultrasonic vocalization test paradigms. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.092 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2009; Published Online: 03 Mar 2009. * Correspondence: Ferenc Kassai, Gedeon Richter Plc., Budapest, Hungary, fe.kassai@richter.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ferenc Kassai Istvan Gyertyan Google Ferenc Kassai Istvan Gyertyan Google Scholar Ferenc Kassai Istvan Gyertyan PubMed Ferenc Kassai Istvan Gyertyan Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.