Synthesis of Unsymmetrically Substituted Bipyridines by Palladium-Catalyzed Direct C−H Arylation of Pyridine N -Oxides
2011; American Chemical Society; Volume: 13; Issue: 9 Linguagem: Inglês
10.1021/ol200565u
ISSN1523-7060
AutoresSasa Duric, Carl Christoph Tzschucke,
Tópico(s)Cyclopropane Reaction Mechanisms
ResumoSubstituted bipyridines were efficiently prepared by direct coupling between pyridine N-oxides and halopyridines using a palladium catalyst. Pyridine N-oxides with electron-withdrawing substituents gave the best yields. This method allows the convenient preparation of 2,2'-, 2,3'-, and 2,4'-bipyridines which are useful as functionalized ligands for metal complexes or as building blocks for supramolecular architectures.
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