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Pharmacology of a Short-Acting Non-Sulphur Barbituric Acid Derivative

1955; SAGE Publishing; Volume: 89; Issue: 2 Linguagem: Inglês

10.3181/00379727-89-21788

1535-3702

W. R. Gibson, Edward E. Swanson, Wilbur J. Doran,

Organic Chemistry Cycloaddition Reactions

A new compound, l-methyl-5-allyl-(1 -methyl-2-pentynyl) barbituric acid, sodium salt, (#22451) has been studied and compared with Pentothal and Thioseconal in rats, rabbits, dogs and monkeys. It is a more potent anesthetic than either Pentothal or Thioseconal. With an observed AD60 this compound has a shorter duration of anesthetic action than the two thio-compounds. When one-half of the AD50 is injected by vein at hourly intervals #22451 shows less cumulative action than Pentothal or Thioseconal. After prolonged anesthesia, recovery time is much more rapid with this agent than with Pentothal or Thioseconal and, as other experiments show, this transient action is related to detoxification by the liver.