Gold Nanoparticle-Decellularized Matrix Hybrids for Cardiac Tissue Engineering
2014; American Chemical Society; Volume: 14; Issue: 10 Linguagem: Inglês
10.1021/nl502673m
ISSN1530-6992
AutoresMichal Shevach, Sharon Fleischer, Assaf Shapira, Tal Dvir,
Tópico(s)Graphene and Nanomaterials Applications
ResumoDecellularized matrices are valuable scaffolds for engineering functional cardiac patches for treating myocardial infarction. However, the lack of quick and efficient electrical coupling between adjacent cells may jeopardize the success of the treatment. To address this issue, we have deposited gold nanoparticles on fibrous decellularized omental matrices and investigated their morphology, conductivity, and degradation. We have shown that cardiac cells engineered within the hybrid scaffolds exhibited elongated and aligned morphology, massive striation, and organized connexin 43 electrical coupling proteins. Finally, we have shown that the hybrid patches demonstrated superior function as compared to pristine patches, including a stronger contraction force, lower excitation threshold, and faster calcium transients.
Referência(s)