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Isolation, Characterization, and NO Inhibitory Activities of Sesquiterpenes from Blumea balsamifera

2012; American Chemical Society; Volume: 60; Issue: 32 Linguagem: Inglês

10.1021/jf302530u

1520-5118

Jing Xu, Da‐Qing Jin, Cuizhou Liu, Chunfeng Xie, Yuanqiang Guo, Lingzhi Fang,

Sesquiterpenes and Asteraceae Studies

Blumea balsamifera belongs to the family Compositae, and its leaves have been used as a flavoring ingredient and a tea. A phytochemical investigation of the aerial parts of B. balsamifera led to the isolation of 10 new (1-10) and 1 known (11) sesquiterpenes. Their structures were elucidated on the basis of extensive one- and two-dimensional nuclear magnetic resonance (heteronuclear multiple-quantum coherence, heteronuclear multiple-bond correlation, (1)H-(1)H correlation spectroscopy, and nuclear Overhauser effect spectrometry) spectroscopic data analyses, and the structure of compound 1 was confirmed by X-ray crystallography. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these sesquiterpenes were evaluated, and all of the compounds showed inhibitory effects.