Palladium-Catalyzed, Ligand-Free Suzuki Reaction in Water Using Aryl Fluorosulfates
2015; American Chemical Society; Volume: 17; Issue: 8 Linguagem: Inglês
10.1021/acs.orglett.5b00654
ISSN1523-7060
AutoresQiaobin Liang, Ping Xing, Zuo‐Gang Huang, Jiajia Dong, K. Barry Sharpless, Xiaoxian Li, Biao Jiang,
Tópico(s)Chemical Synthesis and Analysis
ResumoAryl fluorosulfates were prepared by a simple method and employed as coupling partners in the Suzuki–Miyaura reaction. The cross-coupling reactions were performed in water under air at room temperature without ligands or additives such as surfactants or phase-transfer reagents and proceeded smoothly to give excellent yields. Aryl fluorosulfates could also be used as alternatives to halides or triflates in other coupling reactions.
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