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Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991; Massachusetts Medical Society; Volume: 324; Issue: 20 Linguagem: Inglês

10.1056/nejm199105163242002

1533-4406

Raymond P. Warrell, Stanley R. Frankel, Wilson H. Miller, David A. Scheinberg, Loretta M. Itri, Walter N. Hittelman, Rohini C. Vyas, Michael Andreeff, Agostino Tafuri, Ann A. Jakubowski, Janice Gabrilove, Michael S. Gordon, Ethan Dmitrovsky,

Estrogen and related hormone effects

Patients with acute promyelocytic leukemia have a characteristic (15;17) translocation, with a breakpoint on chromosome 17 in the region of the retinoic acid receptor—alpha (RAR-α). Since this receptor has been shown to be involved with growth and differentiation of myeloid cells in vitro, and since recent clinical studies have reported that tretinoin (all-trans-retinoic acid) induces complete remission in patients with acute promyelocytic leukemia, we studied the effects of tretinoin on cellular maturation and molecular abnormalities in patients undergoing the induction of remission with this agent.