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Assessment of five different guideline indication criteria for spirometry, including modified GOLD criteria, in order to detect COPD: data from 5,315 subjects in the PLATINO study

2014; Nature Portfolio; Volume: 24; Issue: 1 Linguagem: Inglês

10.1038/npjpcrm.2014.75

2055-1010

Ana Paula Luize, Ana Maria Baptista Menezes, Rogelio Pérez‐Padilla, Adriana Muiño, María Victorina López, Gonzalo Valdívia, C Lisboa, María Montes de, Carlos Tálamo, Bartolomé R. Celli, Oliver A. Nascimento, Mariana Rodrigues Gazzotti, José Roberto Jardim,

Respiratory and Cough-Related Research

Spirometry is the gold standard for diagnosing chronic obstructive pulmonary disease (COPD). Although there are a number of different guideline criteria for deciding who should be selected for spirometric screening, to date it is not known which criteria are the best based on sensitivity and specificity. Firstly, to evaluate the proportion of subjects in the PLATINO Study that would be recommended for spirometry testing according to Global initiative for Obstructive Lung Disease (GOLD)-modified, American College of Chest Physicians (ACCP), National Lung Health Education Program (NLHEP), GOLD and American Thoracic Society/European Respiratory Society (ATS/ERS) criteria. Secondly, we aimed to compare the sensitivity, specificity, and positive predictive and negative predictive values, of these five different criteria. Data from the PLATINO study included information on respiratory symptoms, smoking and previous spirometry testing. The GOLD-modified spirometry indication criteria are based on three positive answers out of five questions: the presence of cough, phlegm in the morning, dyspnoea, age over 40 years and smoking status. Data from 5,315 subjects were reviewed. Fewer people had an indication for spirometry (41.3%) according to the GOLD-modified criteria, and more people had an indication for spirometry (80.4%) by the GOLD and ATS/ERS criteria. A low percentage had previously had spirometry performed: GOLD-modified (14.5%); ACCP (13.2%); NLHEP (12.6%); and GOLD and ATS/ERS (12.3%). The GOLD-modified criteria showed the least sensitivity (54.9) and the highest specificity (61.0) for detecting COPD, whereas GOLD and ATS/ERS criteria showed the highest sensitivity (87.9) and the least specificity (20.8). There is a considerable difference in the indication for spirometry according to the five different guideline criteria. The GOLD-modified criteria recruit less people with the greatest sum of sensitivity and specificity. A new study reveals the most useful criteria for indicating spirometry testing in patients with chronic obstructive pulmonary disease (COPD). Spirometry, which assesses lung function by measuring how much air is inhaled and how quickly it is exhaled, is the most accurate diagnostic test for COPD but there are different criteria indicating its use. An international group of researchers led by José R. Jardim, Universidade Federal de São Paulo, Brasil, evaluated the proportion of individuals from a 5,315-patient study carried out in Latin America that met criteria for spirometry testing according to five different guidelines. They found that the modified GOLD (Global Initiative for COPD) criteria, which consider symptoms and history of flare-ups as well as the degree of airflow obstruction, are the most sensitive and specific for diagnosing COPD.