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Association between Pre-Transplant Serum Malondialdehyde Levels and Survival One Year after Liver Transplantation for Hepatocellular Carcinoma

2016; Multidisciplinary Digital Publishing Institute; Volume: 17; Issue: 4 Linguagem: Inglês

10.3390/ijms17040500

1661-6596

Leonardo Lorente, Sergio Rodriguez, Pablo Sanz-Ruíz, Pedro Abreu-González, Dácil Díaz, Antonia Moreno, Elisa Borja, Marı́a Martı́n, Alejandro Jiménez, Manuel Barrera,

Alcohol Consumption and Health Effects

Previous studies have found higher levels of serum malondialdehyde (MDA) in hepatocellular carcinoma (HCC) patients compared to healthy controls and higher MDA concentrations in tumoral tissue of HCC patients than in non-tumoral tissue. However, the association between pre-transplant serum levels of MDA and survival in HCC patients after liver transplantation (LT) has not been described, and the aim of the present study was to determine whether such an association exists. In this observational study we measured serum MDA levels in 127 patients before LT. We found higher pre-LT serum MDA levels in 15 non-surviving than in 112 surviving patients one year after LT (p = 0.02). Exact binary logistic regression analysis revealed that pre-LT serum levels of MDA over 3.37 nmol/mL were associated with mortality after one year of LT (Odds ratio = 5.38; 95% confidence interval (CI) = from 1.580 to infinite; p = 0.007) adjusting for age of the deceased donor. The main finding of our study was that there is an association between serum MDA levels before LT for HCC and 1-year survival after LT.