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Relation Between Absorption and Utilization of Galactose.

1928; SAGE Publishing; Volume: 25; Issue: 6 Linguagem: Inglês

10.3181/00379727-25-3869

1535-3702

C. F. Cori, G. T. Cori,

Diet, Metabolism, and Disease

Previous experiments have shown that when galactose and glucose are absorbed together, the rate of absorption of galactose is greatly reduced. Folin and Berglund had reported previously that in men the sugar excretion is less than one-tenth as great when a mixture of glucose and galactose (100 gm. each) is ingested as the excretion obtained from 100 gm. of galactose when taken alone. They suggested that the extent to which galactose is utilized in the human organism depends on the quantity of available glucose. Corley administered glucose and galactose intravenously and obtained no evidence that the presence of an excess of glucose in the blood increased the ability of the rabbit to utilize circulating galactose. However, when Corley administered glucose and galactose by mouth, the urinary excretion of galactose decreased, in confirmation of the results of Folin and Berglund. These observations made it desirable to establish a more definite relationship between the rate of absorption and the extent of utilization of galactose in the body. Such experiments were made 2 years ago and are now here reported. Experimental. Each group, consisting of 4 to 6 rats, fasted previously for 48 hours, was fed a different amount of galactose by stomach tube, the amount introduced being known in each case. In one series of experiments galactose alone was fed, in a second series a galactose-glucose mixture of equal parts was given, and in a third series, galactose was presented to the rats in the form of lactose. The collection of urine was extended beyond the period of absorption in order to make allowance for any lag in sugar excretion. Figure 1 is a graphic illustration of the average values obtained in these experiments.