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Dideoxyinosine in Children with Symptomatic Human Immunodeficiency Virus Infection

1991; Massachusetts Medical Society; Volume: 324; Issue: 3 Linguagem: Inglês

10.1056/nejm199101173240301

1533-4406

Karina Butler, Robert N. Husson, Frank M. Balis, Pim Brouwers, Janie Eddy, Deborah El-Amin, Janet Gress, Mary E. Hawkins, Paul Jarosinski, Howard B. Moss, David G. Poplack, Sheila Judge Santacroce, David Venzon, Lori Wiener, Pamela L. Wolters, Anisha Philip,

Cytomegalovirus and herpesvirus research

2′,3′-Dideoxyinosine (ddI) is a dideoxynucleoside with potent activity in vitro against the human immunodeficiency virus (HIV). In initial clinical trials in adults, ddI showed evidence of antiretroviral activity with little hematologic toxicity.