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Purification of Thyroid Hormone-Transaminase from Rat Kidney Mitochondria.

1964; SAGE Publishing; Volume: 115; Issue: 1 Linguagem: Inglês

10.3181/00379727-115-28817

1535-3702

Masahiro Nakano, S Tsuchiya, T. S. Danowski,

Metabolism and Genetic Disorders

SummaryCrude transaminase from extracts of rat kidney mitochondria which catalyze the deamination of thyroxine, triiodothyronine and diiodotyrosine was purified by means of a DEAE cellulose column. The elution pattern suggests that the deamination of these three iodinated compounds is effected by one transaminase. Column treatment produced a 3-fold increase in the enzyme.