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Effects of dietary hop β-acids or colistin on the performance, nutrient digestibility, and intestinal health of weanling pigs

2016; Elsevier BV; Volume: 217; Linguagem: Inglês

10.1016/j.anifeedsci.2016.04.007

1873-2216

Maicon Sbardella, Danilo do Prado Perina, Carla de Andrade, Cauê Bastos Tertuliano dos Santos, Pedro Leon Gomes Cairo, Eric de Lima Silva Marques, Rachel Passos Rezende, Leandro Batista Costa, Valdomiro Shigueru Miyada,

Powdery Mildew Fungal Diseases

Abstract The purpose of this study was to evaluate the effects of dietary graded levels of hop ( Humulus lupulus ) β-acids or colistin on the growth performance, nutrient and energy digestibility, diarrhea occurrence, unthrifty pigs, blood respiratory burst, organ weights, small intestine histology, and intestinal microbial diversity of weanling pigs, as well as in vitro bacterial sensitivity to hop β-acids. Two hundred 21-d weaned castrated male and female pigs (6.2 ± 0.33 kg initial BW) were used in a randomized complete block design experiment with 5 treatments, 8 replicates, and 5 pigs per experimental unit (pen). Pigs were fed corn-soybean meal basal diets supplemented with 0 (negative control), 120, 240, or 360 mg/kg hop β-acids, or with 40 mg/kg colistin (antimicrobial control) during a 35-d nursery feeding experiment. On d 7 and 35 of the experiment, one castrated male from each pen was slaughtered to evaluate organ weights, small intestine histology, and intestinal microbial diversity. ANOVA and orthogonal contrasts were performed to determine the dose-response of each variable to dietary hop β-acids levels (0, 120, 240, and 360 mg/kg), as well as to compare the means of antimicrobial control with the negative control and with each dietary hop β-acids level. Increasing dietary levels of hop β-acids improved linearly ( P P P Staphylococcus aureus was sensitive to hop β-acids (33.1 ± 2.57 mm inhibition zone), while Escherichia coli , Salmonella enteritidis , Salmonella typhimurim , and Enterococcus faecalis were resistant. In conclusion, dietary hop β-acids concentrations up to 360 mg/kg improved weanling pig growth rate by affecting the efficiency of feed utilization, as well as observed for colistin.