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Anti-inflammatory and antinociceptive activities of Bauhinia monandra leaf lectin

2016; Elsevier BV; Volume: 2; Linguagem: Inglês

10.1016/j.biopen.2016.03.001

2214-0085

Janaína Karin Lima Campos, Chrisjacele Santos Ferreira de Araujo, Tiago Ferreira da Silva Araújo, Andréa F. S. Santos, J. A. Teixeira, Vera Lúcia de Menezes Lima, Luana Cassandra Breitenbach Barroso Coelho,

Pharmacological Effects of Natural Compounds

A galactose-specific lectin from Bauhinia monandra leaves (BmoLL) has been purified through ammonium sulfate fractionation followed by guar gel affinity chromatography column. This study aimed to evaluate the potential anti-inflammatory and antinociceptive activity of pure BmoLL in mice. Anti-inflammatory activity was evaluated by 1% carrageenan-induced inflammation in mice treated with BmoLL. Acetic acid-induced abdominal writhing and hot plate methods evaluated antinociceptive activity. BmoLL significantly inhibited the carrageenan-induced paw edema by 47% (30 mg/kg) and 60.5% (60 mg/kg); acetylsalicylic acid (ASA, 100 mg/kg) showed inhibition of 70.5%, in comparison to controls. Leukocyte migration, an immune response to the inflammation process, was significantly reduced in presence of BmoLL; in mice treated with ASA the decrease in leukocyte migration was similar to 15 mg/kg of the lectin. BmoLL at doses of 15, 30 and 60 mg/kg significantly reduced the number of animal contortions by 43.1, 50.1 and 71.3%, respectively. BmoLL leukocyte migration was significantly reduced; in mice treated with ASA the decrease in leukocyte migration was similar to 15 mg/kg of the lectin. BmoLL at doses of 15, 30 and 60 mg/kg significantly reduced the number of animal contortions by 43.1, 50.1 and 71.3%, respectively. The lectin (30 and 60 mg/kg) showed a significant effect in the hot plate assay. BmoLL anti-inflammatory and antinociceptive effects were dose-dependent. The search for new and natural compounds, with minimal side effects, to control pain and inflammation, is constantly increasing. BmoLL has great potential as a natural anti-inflammatory product that can be explored for pharmacological purposes.