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Modification of Post-Transfusion Hepatitis by Gamma Globulin

1965; Massachusetts Medical Society; Volume: 273; Issue: 2 Linguagem: Inglês

10.1056/nejm196507082730201

1533-4406

George S. Mirick, Robert Ward, Robert W. McCollum,

Liver Disease Diagnosis and Treatment

THE following report presents the results of studies carried out to evaluate the effectiveness of gamma globulin in the prophylaxis of post-transfusion hepatitis. Some preliminary results have already been published in abstract form.1 , 2 The detected incidence of post-transfusion hepatitis varies with the method and the intensity and duration of follow-up observations. Icteric hepatitis has been reported to occur at the rate of 1 to 15 cases per thousand units of blood,3 4 5 6 7 8 but in most series it has ranged from 1 to 3 cases. Recent reports9 , 10 suggest that nonicteric hepatitis after transfusion may be ten or more times as common as . . .