Physiological aspects of low-density lipoprotein oxidation
2000; Lippincott Williams & Wilkins; Volume: 11; Issue: 3 Linguagem: Inglês
10.1097/00041433-200006000-00011
ISSN1473-6535
Autores Tópico(s)Cardiovascular, Neuropeptides, and Oxidative Stress Research
ResumoThe oxidation of LDL is thought to be a major contributor to the development of atherosclerosis. Considerable descriptive evidence has been accumulated showing that oxidized LDL promotes pro-atherogenic events. However, direct evidence that oxidized LDL causes atherosclerosis is lacking. This article summarizes the results of recent studies that demonstrate how oxidized LDL affects cellular function, and highlights key issues that should be addressed to link LDL oxidation with atherosclerosis.
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