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HPV types in Turkey: multicenter hospital based evaluation of 6388 patients in turkish gynecologic oncology group centers

2013; Federation of Turkish Pathology Societies; Volume: 29; Issue: 3 Linguagem: Inglês

10.5146/tjpath.2013.01188

1309-5730

Polat Dursun, Ali Ayhan, Levent Mutlu, Mete Çağlar, Alı Haberal, Taygun Gungor, Mustafa Özat, Emre Özgü, Anıl Onan, Çağatay Taşkıran, Haldun Güner, Hakan Yetimalar, Burcu Kasap, K. Yüce, M. C. Salman, Berkan Sayal, Selen Doğan, Müge Harma, Mehmet Harma, Mustafa Başaran, Hüseyin Aydoğmuş, Yusuf Ergün, Salim Șehirali, Emre Gültekin, Şükran Köse, Yusuf Yıldırım, Müfit Cemal Yenen, Murat Dede, İbrahim Alanbay, Rıza Efendi Karaca, Jale Metindir, Hüseyin Levent Keskin, İşık Üstüner, Filiz Avşar, Hasan Yüksel, Selim Kirdar,

Head and Neck Cancer Studies

Objective: To evaluate the prevalence of HPV DNA and cervical cytological abnormalities, to compare cervical cytology results and HPV DNA and to define HPV types distribution in a large series of Turkish women who have undergone HPV analysis in hospitals that are members of the Turkish Gynecological Oncology Group.Material and Method: Between 2006 and 2010, a total of 6388 patients' data was retrospectively evaluated at 12 healthcare centers in Turkey.Demographic characteristics, cervical cytology results, HPV status and types were compared.Results: Th e mean age of the patients was 38.9±10.2.Overall, 25% of the women were found to be HPV positive.Presence of HPV-DNA among patients with abnormal and normal cytology was 52% and 27%, respectively.Th ere was significant diff erence with respect to decades of life and HPV positivity (p < 0.05).HPV was positive in (within the HPV (+) patients) 37%, 9%, 27%, 20%, 22%, and 41% of the ASCUS, ASC-H, LSIL HSIL, glandular cell abnormalities, and SCC cases respectively Th e most common HPV types in our study were as follows; HPV 16 (32%), HPV 6 (17%), HPV 11 (9%), HPV 18 (8%), HPV 31 (6%), HPV 51 (5%), HPV 33 (3%). Conclusion:In this hospital based retrospective analysis, HPV genotypes in Turkish women with normal and abnormal cytology are similar to those reported from western countries.Further population based prospective multicenter studies are necessary to determine non-hospital based HPV prevalence in Turkish women.