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<i>In Vitro</i> Anticancer Assessment of <i>Annickia chlorantha</i> (Oliv.) Setten & Maas Stem (Annonaceae) Bark from Democratic Republic of Congo

2016; Volume: 04; Issue: 04 Linguagem: Inglês

10.4236/jbm.2016.44004

2327-509X

Damien S. T. Tshibangu, S. Divakar, Muthiah Ramanathan, Govindarajan Syamala, Koto-te-Nyiwa Ngbolua, Jean Chrysostome V. Mudogo, Dinangayi D. Tshilanda, Nicole M. Misengabu, Pius T. Mpiana,

Phytochemistry and Biological Activities

In this study, we evaluated the anti-cancer property of five bark extracts and the isolates from chloroform and ethyl acetate of Annickia chlorantha by the tetrazolium salt method (MTT method). The anti-cancer activity was performed on human prostate cancer cell lines PC-3 and hormone-dependent breast cancer cell lines MCF-7. Results indicated that the two isolates displayed interesting cytotoxicity towards MCF-7 cell lines with CC50 of 3.84 CC50/mL and 4.87 CC50/mL for chloroform and ethyl acetate respectively; while the total bark extracts showed CC50 of 24.33 CC50/mL, 36.49 CC50/ mL and 73.52 CC50/mL for chloroform, ethyl acetate and methanol extracts respectively. By the other hand on PC-3, the CC50 of the isolates were higher than the one on MCF-7, more than 10 CC50/mL for both chloroform and ethyl acetate isolates and 49.14 CC50/mL, 77.33 CC50/mL, 89.38 CC50/mL and 92.37 CC50/mL, respectively for chloroform, ethyl acetate and methanol soluble extracts. From this study, we identified that the two isolates had anti-cancer properties against MCF-7 cell lines.