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Early Stages of Enterovirus Infection

1962; Cold Spring Harbor Laboratory Press; Volume: 27; Linguagem: Inglês

10.1101/sqb.1962.027.001.013

1943-4456

John J. Holland, Bill H. Hoyer,

Bacteriophages and microbial interactions

In contrast to our knowledge of certain phage systems, very little is known of the mechanisms by which most animal viruses attach to and enter host cells, and release their nucleic acid genome from its protective capsid. This paper will briefly review studies carried out by ourselves and others on these early stages in enterovirus infection, and will present new evidence for physical effects on virus resulting from interaction with cell membrane receptors. Much of our earlier work reviewed here was done in collaboration with L. C. McLaren and the late J. T. Syverton.