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Application of a New Dye for Near-Infrared Fluorescence Laparoscopy of the Ureters

2014; Lippincott Williams & Wilkins; Volume: 57; Issue: 3 Linguagem: Inglês

10.1097/dcr.0000000000000055

1530-0358

Rutger M. Schols, Toine M. Lodewick, Nicole D. Bouvy, Gooitzen M. van Dam, Cornelis H.C. Dejong, Laurents P. S. Stassen,

Urological Disorders and Treatments

Ureteral injury during laparoscopic colorectal surgery is a rare but serious complication with a reported incidence rate of 0.66%. The early detection and prevention of ureteral injury is clinically relevant and important. The successful use of preclinical near-infrared fluorophore CW800-CA for real-time intraoperative identification of the anatomical course of the ureters with the use of a laparoscopic fluorescence imaging system is reported.The usefulness of this new imaging technique was explored in two 35-kg pigs. Intravenous CW800-CA was administered 10 minutes before fluorescence imaging was conducted with the use of a commercially available laparoscopic fluorescence imaging system.A dose of 1 mg/mL CW800-CA (bolus injection of 3 mL) provided clear delineation of the course of both ureters by using the fluorescence mode of the laparoscope. There were no adverse reactions to the injected dye.Near-infrared fluorescence laparoscopy of the ureters, following intravenous CW800-CA administration, is easily applicable and provides real-time identification of the course of the ureters.