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A New Versatile Matrix for Fast Atom Bombardment Mass Spectrometry.

1998; Mass Spectrometry Society of Japan; Volume: 46; Issue: 2 Linguagem: Inglês

10.5702/massspec.46.143

1880-4225

Mitsuo Takayama, Hiromi Kataoka, Toyoshi Katagi, Shizuyo Horiyama, Masae Yamaki, Fukiko Hasegawa, Zeper Abliz,

Mass Spectrometry Techniques and Applications

A new liquid matrix referred to as DTT/NBA, a 1 : 1 (v/v) mixture of dithiothreitol (DTT) and m-nitrobenzyl alcohol (NBA), has been prepared on the basis of a criterion for the choice of matrix in fast atom bombardment mass spectrometry. The capability of DTT/NBA was examined by comparing with those of conventional matrices from the points of durability and chemical inertness. The durability of DTT/NBA was more than ten minutes under the irradiation of fast atom beam, and the mass spectral patterns obtained little varied over the irradiation time. The DTT/NBA matrix inhibited from a degradation reaction of O-acyl oximes, while conventional matrices used here brought about a reductive degradation.