Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. I. Taxonomy, fermentation, isolation and biological activity.
1993; Springer Nature; Volume: 46; Issue: 5 Linguagem: Inglês
10.7164/antibiotics.46.719
ISSN1881-1469
AutoresMitsuhiro Ueno, Masahide Amemiya, Masatomi Iijima, Michiyo Osono, Toru Masuda, Naoko Kinoshita, Takako Ikeda, HIRONOBU IINUMA, MASA HAMADA, Masaaki Ishizuka, TOMIO TAKEUCHI,
Tópico(s)Cell Adhesion Molecules Research
ResumoIn order to develop a new class of immunomodulator we have searched for a low molecular weight inhibitors of cell adhesion to components of extracellular matrix (ECM), fibronectin (FN), laminin (LM) and collagen type IV (CL), and succeeded to find a group of novel antibiotics, named delaminomycins. Delaminomycins were isolated from the mycelium and cultured broth of Streptomyces albulus MJ202-72F3. It was purified by use of centrifugal partition chromatography (CPC), preparative reverse phase HPLC and Sephadex LH-20 and was obtained as a white powder. Delaminomycins with inhibitory activity for cell adhesion to ECM components suppressed immune responses in vitro and in vivo and exhibited antimicrobial activity on Gram-positive bacteria.
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