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Histone H1 Involvement in the Structure of the Chromosome Fiber

1978; Cold Spring Harbor Laboratory Press; Volume: 42; Linguagem: Inglês

10.1101/sqb.1978.042.01.026

1943-4456

Manfred Renz, Peter Nehls, John Hozier,

RNA and protein synthesis mechanisms

There now seems to be little doubt that DNA in the nucleus of eukaryotic cells is in the form of very long, continuous molecules, probably thousands of times as long as the largest dimension of the nucleus. All of this DNA must be folded in such a way that it fits within the interphase nucleus and yet maintains its functional capacity. Since the degree of condensation is so large, there are most likely several “levels” of folding of the DNA molecule. The two basic levels of folding — the formation of nucleosomes and the folding of nucleosome chains into chromosome fibers — seem to be due solely to the interactions of DNA and histones.