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Symmetrical and Asymmetrical Cyanine Dyes. Synthesis, Spectral Properties, and BSA Association Study

2014; American Chemical Society; Volume: 79; Issue: 12 Linguagem: Inglês

10.1021/jo500657s

1520-6904

Diego S. Pisoni, Letícia Todeschini, Antonio C. A. Borges, César Liberato Petzhold, Fabiano Severo Rodembusch, Leandra Franciscato Campo,

Porphyrin and Phthalocyanine Chemistry

New cyanines were prepared by an efficient and practical route with satisfactory overall yield from low-cost starting materials. The photophysical behavior of the cyanines was investigated using UV-vis and steady-state fluorescence in solution, as well as their association with bovine serum albumin (BSA) in phosphate buffer solution (PBS). No cyanine aggregation was observed in organic solvents or in phosphate buffer solution. The alkyl chain length in the quaternized nitrogen was shown to be fundamental for BSA detection in PBS in these dyes.