Central anticholinergic syndrome from orphenadrine in a 3 year old
2000; Lippincott Williams & Wilkins; Volume: 16; Issue: 2 Linguagem: Inglês
10.1097/00006565-200004000-00008
ISSN1535-1815
AutoresMary B. Garza, Kevin C. Osterhoudt, Richard M. Rutstein,
Tópico(s)Epilepsy research and treatment
ResumoOrphenadrine (N,N-dimethyl-2(o-methyl-alpha-phenylbenzyloxy)ethylamine) is an analog of diphenhydramine with central and peripheral anticholinergic properties. It is commonly prescribed both as a muscle relaxant and as an adjunct to antipsychotic medications to prevent parkinsonism. We report a case of orphenadrine poisoning in a 3-year-old boy following ingestion of no more than two 100-mg tablets. Central anticholinergic toxicity was prominent, manifested by hallucinations and severe agitation. Orphenadrine can cause profound toxicity in children after ingestion of small doses, and should be considered as a potential cause for acute delirium in childhood.
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