Studies on cell growth stimulating substances of low molecular weight. Part 3. Resorcinin, a mammalian cell growth stimulating substance produced by Cytophaga johnsonae.
1993; Springer Nature; Volume: 46; Issue: 8 Linguagem: Inglês
10.7164/antibiotics.46.1319
ISSN1881-1469
AutoresShinsuke Imai, Kohtaro Fujioka, Kazuo Furihata, Ryosuke Fudo, Shigeru Yamanaka, Haruo Seto,
Tópico(s)Bioactive Compounds and Antitumor Agents
ResumoIn the course of our screening program for mammalian cell growth stimulating substances1'2), a gliding bacterium, Cytophaga johnsonae AJ No. 12589, isolated from Kanagawa Prefecture, Japan, was found to produce a substance stimulating the growth of NIH 3T3 mouse fibroblast cells in the presence of only 1% of fetal calf serum (FCS).Without addition of this substance, the cells did not show any growth under the same conditions.In this communication, we report isolation, characterization, and structural elucidation of the compound namedresorcinin.Cytophagajohnsonae AJ No. 1 2589 was cultivated at 28°C in a 30-liter jar fermentor containing the medium composed ofcasitone 2% and MgCl2 0.2%
Referência(s)