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SYNTHESIS AND BIOLOGICAL EVALUATION OF 1H-PYRAZOLO [3,4-b] PYRIDINE-5 CARBOXYLIC ACIDS AGAINST VACCINIA VIRUS

2002; De Gruyter; Volume: 8; Issue: 5 Linguagem: Inglês

10.1515/hc.2002.8.5.427

2191-0197

A. Azevedo, Vı́tor F. Ferreira, Heloisa de Mello, Luiz R. Leão-Ferreirab, Alfredo V. Jabor, Izabel C.P.P. Frugulhetti, Helena de Souza Pereira, Nissin Moussatché, Alice M. R. Bernardino,

Research on Leishmaniasis Studies

Several new 3-phenyl and 3-alky 1-l//-pyrazolo[3,4-Z>]pyridine derivatives (3a-e) were prepared and evaluated against Vaccinia virus on BSC-40 cells.The derivatives 3a, 3b and 3d showed an inhibitory activity above 90% at 30 μΜ, 40 μΜ and 50 μΜ concentrations.