Artigo Revisado por pares

Au–Cu 2– x Se Heterodimer Nanoparticles with Broad Localized Surface Plasmon Resonance as Contrast Agents for Deep Tissue Imaging

2013; American Chemical Society; Volume: 13; Issue: 9 Linguagem: Inglês

10.1021/nl402124h

ISSN

1530-6992

Autores

Xin Liu, Changho Lee, Wing‐Cheung Law, Dewei Zhu, Maixian Liu, Mansik Jeon, Jeehyun Kim, Paras N. Prasad, Chulhong Kim, Mark T. Swihart,

Tópico(s)

Nanoplatforms for cancer theranostics

Resumo

We report a new type of heterogeneous nanoparticles (NPs) composed of a heavily doped semiconductor domain (Cu2-xSe) and a metal domain (Au), which exhibit a broad localized surface plasmon resonance (LSPR) across visible and near-infrared (NIR) wavelengths, arising from interactions between the two nanocrystal domains. We demonstrate both in vivo photoacoustic imaging and in vitro dark field imaging, using the broad LSPR in Cu2-xSe-Au hybrid NPs to achieve contrast at different wavelengths. The high photoacoustic imaging depth achieved, up to 17 mm, shows that these novel contrast agents could be clinically relevant. More broadly, this work demonstrates a new strategy for tuning LSPR absorbance by engineering the density of free charge carriers in two interacting domains.

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