Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear
2014; American Chemical Society; Volume: 77; Issue: 4 Linguagem: Inglês
10.1021/np400323u
ISSN1520-6025
AutoresXing‐Rong Peng, Jie‐Qing Liu, Cuifang Wang, Xu-Yang Li, Yi Shu, Lin Zhou, Ming‐Hua Qiu,
Tópico(s)Essential Oils and Antimicrobial Activity
ResumoTwo novel trinorlanostanes, cochlates A and B (1 and 2), with a 3,4-seco-9,10-seco-9,19-cyclo skeleton, as well as six new triterpenoids, fornicatins D–F (3–5) and ganodercochlearins A–C (6–8), together with five known triterpenoids (9–13), were obtained from the fruiting bodies of Ganoderma cochlear. The structural elucidation was achieved by interpretation of spectroscopic data, and compounds 2 and 7a were further characterized by X-ray crystallographic analysis. Fornicatins A, D, and F (10, 3, and 5) and fredelin (13) lowered the ALT and AST levels in HepG2 cells treated with H2O2, suggesting that they could display in vivo hepatoprotective activities.
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