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Early inflammatory events associated with chronic allograft rejection

1999; Lippincott Williams & Wilkins; Volume: 4; Issue: 1 Linguagem: Inglês

10.1097/00075200-199903000-00003

1531-7013

Markus J. Wilhelm, Johann Pratschke, Dustin Paz, Igor Laskowski, Nicholas L. Tilney,

Renal Transplantation Outcomes and Treatments

The ongoing investigative efforts to understand the causes, evolution, and pathophysiology of chronic allograft rejection have become a major subject of transplantation research. Because of the persistent rate of attrition of many engrafted organs, a sequential definition of the process is desired to produce new prevention strategies. Early inflammatory events secondary to initial non-specific graft injury are increasingly recognized as playing a critical role in the development of later functional and structural changes. Thus, gaining further insight into these early processes may be an important prerequisite for effective manipulation of the overall chronic process. Recent information surrounding such initial events is reviewed in this article. In addition, the effects of ischemia-reperfusion injury and cytomegalovirus infection, both of which are considered particularly important, are described.