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Efficient Access to 1,4-Benzothiazine: Palladium-Catalyzed Double C–S Bond Formation Using Na 2 S 2 O 3 as Sulfurating Reagent

2013; American Chemical Society; Volume: 15; Issue: 11 Linguagem: Inglês

10.1021/ol400618k

1523-7060

Zongjun Qiao, Hui Liu, Xiao Xiao, Yana Fu, Jianpeng Wei, Yuxue Li, Xuefeng Jiang,

Synthesis and Catalytic Reactions

A novel Pd-catalyzed double C–S bond formation coupling reaction has been developed. This protocol, in which Na2S2O3 was used as sulfurating reagent in metal-catalyzed reactions, provides an efficient method for the synthesis of substituted 1,4-benzothiazine derivates, which are structural elements of numerous bioactivity molecules rendering this protocol attractive to both synthetic and medicinal chemistry.