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The genome anatomy of Corynebacterium pseudotuberculosis VD57 a highly virulent strain causing Caseous lymphadenitis

2016; Springer Science+Business Media; Volume: 11; Issue: 1 Linguagem: Inglês

10.1186/s40793-016-0149-7

1944-3277

S. Almeida, Sandeep Tiwari, Diego Mariano, Flávia de Oliveira Souza, Syed Babar Jamal, Nilson Da Rocha Coimbra, Roberto Tadeu Raittz, Fernanda Alves Dorella, Alex F. Carvalho, Felipe Luiz Pereira, Siomar de Castro Soares, Carlos Augusto Gomes Leal, Debmalya Barh, Preetam Ghosh, Henrique César Pereira Figueiredo, Lília Ferreira de Moura‐Costa, Ricardo Wagner Portela, Roberto Meyer, Artur Silva, Vasco Azevedo,

Bacterial Identification and Susceptibility Testing

Abstract Corynebacterium pseudotuberculosis strain VD57 (Cp_VD57), a highly virulent, nonmotile, non-sporulating, and a mesophilic bacterium, was isolated from a goat’s granulomatous lesion in the municipality of Juazeiro, Bahia State, Brazil. Here, we describe a set of features of the strain, together with the details of its complete genome sequence and annotation. The genome comprises of a 2.5 Mbp long, single circular genome with 2,101 protein-coding genes, 12 rRNA, 49 tRNA and 47 pseudogenes and a G + C content of 52.85 %. Genetic variation was detected in Cp_VD57 using C. pseudotuberculosis strain 1002 as reference, wherein small genomic insertions and deletions were identified. The comparative analysis of the genome sequence provides means to better understand the host pathogen interactions of this strain and can also help us to understand the molecular and genetic basis of virulence of this bacterium.