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Development of an Air-Stable Nickel Precatalyst for the Amination of Aryl Chlorides, Sulfamates, Mesylates, and Triflates

2013; American Chemical Society; Volume: 16; Issue: 1 Linguagem: Inglês

10.1021/ol403209k

1523-7060

Nathaniel H. Park, Georgiy Teverovskiy, Stephen L. Buchwald,

Catalytic C–H Functionalization Methods

A new air-stable nickel precatalyst for C–N cross-coupling is reported. The developed catalyst system displays a greatly improved substrate scope for C–N bond formation to include both a wide range of aryl and heteroaryl electrophiles and aryl, heteroaryl, and alkylamines. The catalyst system is also compatible with a weak base, allowing the amination of substrates containing base-sensitive functional groups.